Daisuke Kudo Selected Research

Hymecromone

1/2019	Increase of Tumor Infiltrating γδ T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone.
1/2017	4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells.
10/2016	Antitumor effects of the hyaluronan inhibitor 4-methylumbelliferone on pancreatic cancer.
1/2006	4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells.
5/2005	A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.
9/2004	Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion.

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Daisuke Kudo Research Topics

Disease

27	Neoplasms (Cancer) 10/2020 - 04/2003
20	Sepsis (Septicemia) 01/2022 - 05/2008
11	Neoplasm Metastasis (Metastasis) 03/2022 - 05/2005
11	Disseminated Intravascular Coagulation 01/2019 - 01/2016
11	Wounds and Injuries (Trauma) 03/2017 - 03/2010
8	Pancreatic Neoplasms (Pancreatic Cancer) 12/2018 - 01/2006
7	Renal Cell Carcinoma (Grawitz Tumor) 10/2018 - 04/2003
5	Septic Shock (Toxic Shock Syndrome) 08/2021 - 01/2016
5	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2019 - 08/2013
5	Hemorrhage 09/2018 - 11/2010
4	Kyphosis 01/2021 - 01/2017
4	Inflammation (Inflammations) 12/2020 - 01/2016
4	Multiple Myeloma 01/2019 - 08/2010
4	Melanoma (Melanoma, Malignant) 03/2017 - 09/2004
3	Pain (Aches) 09/2019 - 05/2017
3	Adenocarcinoma 01/2019 - 01/2017
3	Cholangiocarcinoma 12/2018 - 11/2013
3	Colorectal Neoplasms (Colorectal Cancer) 08/2017 - 11/2009
3	Hypothermia 01/2017 - 02/2014
2	Scoliosis 09/2021 - 03/2015
2	Traumatic Brain Injuries (Traumatic Brain Injury) 09/2021 - 01/2017
2	Sarcopenia 03/2021 - 01/2018
2	Lordosis 01/2020 - 01/2018
2	Intracranial Aneurysm (Cerebral Aneurysm) 01/2019 - 10/2018
2	Hypertension (High Blood Pressure) 01/2019 - 10/2018
2	Aneurysm (Aneurysms) 01/2019 - 10/2018
2	Lymphatic Metastasis 12/2018 - 01/2017
2	Congenital Abnormalities (Deformity) 06/2018 - 01/2017
2	Spinal Stenosis (Stenosis, Spinal) 06/2018 - 01/2018
2	Surgical Wound Infection 01/2018 - 12/2017
2	Infections 01/2018 - 01/2017
2	Acidosis 01/2017 - 09/2016
2	Out-of-Hospital Cardiac Arrest 01/2017 - 01/2016
2	Critical Illness (Critically Ill) 10/2016 - 02/2007
2	Klatskin Tumor 06/2015 - 05/2015
2	Burns 02/2012 - 02/2007
1	Breast Neoplasms (Breast Cancer) 03/2022
1	Paraplegia (Spastic Paraplegia) 01/2022
1	Hydronephrosis 10/2021
1	Intracranial Hypertension 09/2021

Drug/Important Bio-Agent (IBA)

11	Dacarbazine (DIC)FDA LinkGeneric 01/2019 - 01/2016
8	Gemcitabine FDA Link 12/2018 - 01/2006
6	HymecromoneIBA 01/2019 - 09/2004
6	Indicators and Reagents (Reagents)IBA 01/2017 - 01/2014
5	ThrombomodulinIBA 01/2022 - 01/2016
5	Hyaluronic Acid (Hyaluronan)IBA 01/2019 - 05/2005
5	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2003
4	Bortezomib (Velcade)FDA Link 01/2019 - 08/2010
4	AnticoagulantsIBA 01/2019 - 01/2016
4	AntithrombinsIBA 09/2018 - 01/2016
4	GangliosidesIBA 04/2008 - 04/2003
3	Anti-Bacterial Agents (Antibiotics)IBA 12/2020 - 12/2016
3	Fibrinogen (Factor I)FDA Link 03/2017 - 03/2016
3	Cytochromes c (Cytochrome c)IBA 04/2008 - 04/2003
3	Hyaluronan SynthasesIBA 01/2006 - 09/2004
2	Diphosphonates (Bisphosphonates)IBA 03/2022 - 10/2020
2	BESIBA 03/2021 - 01/2020
2	fibrin fragment D (D-dimer)IBA 01/2021 - 03/2016
2	Denosumab FDA Link 10/2020 - 01/2020
2	Durapatite (Hydroxylapatite)IBA 01/2020 - 06/2018
2	Pancreatic Elastase (Elastase)IBA 01/2019 - 10/2018
2	Cisplatin (Platino)FDA LinkGeneric 12/2018 - 11/2013
2	ChemokinesIBA 02/2018 - 02/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 03/2008
2	RNA (Ribonucleic Acid)IBA 01/2018 - 03/2015
2	Messenger RNA (mRNA)IBA 01/2018 - 03/2015
2	Immunoglobulin G (IgG)IBA 01/2017 - 02/2014
2	CreatinineIBA 12/2016 - 12/2013
2	Oxygen (Dioxygen)IBA 10/2016 - 02/2007
2	Lactic Acid (Lactate)FDA LinkGeneric 10/2016 - 01/2016
2	Mitochondrial DNA (mtDNA)IBA 01/2016 - 12/2013
2	Irinotecan (Camptosar)FDA LinkGeneric 05/2015 - 11/2009
2	Thalidomide (Thalomid)FDA Link 12/2011 - 08/2010
2	NitritesIBA 05/2008 - 02/2007
2	NitratesIBA 05/2008 - 02/2007
2	LigandsIBA 04/2008 - 02/2007
2	CaspasesIBA 04/2008 - 04/2003
2	NF-kappa B (NF-kB)IBA 03/2008 - 03/2004
2	pneumococcal purpura-producing principle (PPPP)IBA 03/2004 - 04/2003
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 09/2003 - 04/2003
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022

Therapy/Procedure

19	Therapeutics 01/2022 - 08/2010
13	Drug Therapy (Chemotherapy) 12/2018 - 11/2009
7	Resuscitation 01/2017 - 03/2010
4	Critical Care (Surgical Intensive Care) 09/2021 - 03/2017
4	Pancreaticoduodenectomy 12/2018 - 01/2017
4	Adjuvant Chemotherapy 12/2018 - 11/2011
4	Blood Transfusion (Blood Transfusions) 01/2017 - 11/2010
3	Decompression 01/2021 - 01/2018
3	Laminoplasty 01/2020 - 06/2018
2	Activities of Daily Living (ADL) 01/2020 - 01/2017
2	Laminectomy 11/2019 - 06/2018
2	Spinal Fusion (Spondylosyndesis) 09/2019 - 01/2019
2	Pancreatectomy 12/2018 - 12/2018
2	Splenectomy 12/2018 - 12/2018
2	Hepatectomy 11/2018 - 11/2009
2	Laparotomy 11/2013 - 01/2009
1	Foot Orthoses 01/2022
1	Length of Stay 10/2021
1	Operative Surgical Procedures 09/2021